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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: Among them, a mechanistic target of rapamycin kinase (mTOR) inhibitor, which is a macrolide compoundand a cell proliferation inhibitor, was the most promising candidate for targeting SMPP.

Keywords： >Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein     mechanistictarget of rapamycin kinase inhibitor    

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Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 467-482 doi: 10.1007/s11684-021-0869-y

Abstract: cells showed primary resistance to cMet inhibitors, and the combination of cabozantinib and mammalian targetof rapamycin (mTOR) inhibitor, rapamycin, exhibited a synergistic inhibitory effect on the in vitroMechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition ofof human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistantIn conclusion, our findings uncover a potential combination therapy of cabozantinib and rapamycin to

Keywords： hepatocellular carcinoma     cabozantinib     primary resistance     rapamycin    

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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathwaysSo far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while moreMost of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitiveinhibitors and their therapeutic roles in the treatment of diseases are helpful for the illumination of MAP kinase

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract:

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming theacquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitorresistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: Phosphatidylinositol 3-kinase (PI3K) is a crucial cell survival pathway implicated in tumorigenesis becauseThis study was to investigate the regulation of proliferation and apoptosis by LY294002, an inhibitor

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitory    

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Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 273-283 doi: 10.1007/s11684-019-0728-2

Abstract: Up until 2017, treatment of advanced HCC was largely limited to sorafenib, an oral tyrosine kinase inhibitorAs of 2019, the US FDA has approved four oral tyrosine kinase inhibitors, two immune checkpoint inhibitorsThe use of immune checkpoint inhibitors in conjunction with oral tyrosine kinase inhibitors or anti-angiogenesis

Keywords： hepatocellular carcinoma     tyrosine kinase inhibitor     check point inhibitor     anti-angiogenesis    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF.

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1631-2

Abstract:

● All 1,4-naphthoquinone hybrids exhibited significant antimicrobial activity.

Keywords： 1     4-naphthoquinone derivatives     Antibacterial     Action mechanism     RecA    

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Mechanistic insights into the selective photocatalytic degradation of dyes over TiO/ZSM-11

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1701-5

Abstract:

● TiO2/ZSM-11 was prepared by a facile solid state dispersion method.

Keywords： Selective dye degradation     Photocatalysis     TiO2     ZSM-11     Chemisorption    

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Recent advances in cycloaddition of CO with epoxides: halogen-free catalysis and mechanistic insights

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1879-1894 doi: 10.1007/s11705-023-2354-4

Abstract: systematically discussed the halogen-free catalysis for cycloaddition of CO2 with epoxides from the mechanistic

Keywords： carbon dioxide     halogen-free catalysis     cyclic carbonate     mechanistic insight    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: novel drugs on appropriate tumor models has become crucial for developing more effective therapies that targetTreating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK1 inhibitor

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Improved film evaporator for mechanistic understanding of microwave-induced separation process

Xin Gao, Dandan Shu, Xingang Li, Hong Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 4,   Pages 759-771 doi: 10.1007/s11705-019-1816-1

Abstract: Microwave-induced film evaporation separation process has been reported recently to separate the polar/nonpolar mixture. However, the efficiency of the separation is still too low for practical applications, which requires further enhancement via different strategies such as optimization design of evaporator structure. In addition the depth understanding of the separation mechanisms is great importance for better utilization of the microwave-induced separation process. To carry out these investigations, a novel microwave-induced falling film evaporation instrument was developed in this paper. The improvement of the enhancement effect of microwave-induced separation was observed based on the improved film evaporator. The systematic experiments on microwave-induced separation with different binary azeotropic mixtures (ethanol-ethyl acetate system and dimethyl carbonate (DMC)-H O system) were conducted based on the new evaporator. For the ethanol-ethyl acetate system, microwave irradiation shift the direction of evaporation separation at higher ethanol content in the starting liquid mixture. Moreover, for DMC-H O system microwave-induced separation process broke through the limitations of the traditional distillation process. The results clearly demonstrated the microwave-induced evaporation separation process could be commendably applied to the separation of binary azeotrope with different dielectric properties. Effects of operating parameters are also investigated to trigger further mechanism understanding on the microwave-induced separation process.

Keywords： process intensification     microwave     falling film evaporation     separation     azeotrope    

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doping boosted low-temperature NH-SCR activity of FeTiO catalyst: A microstructure analysis and reaction mechanistic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-022-1539-2

Abstract:

• CeO2 doping significantly improved low-temperature NH3-SCR activity on FeTiOx.

Keywords： NH3-SCR     CeO2 doping     Low-temperature NOx removal     Improved redox property     In situ XAFS analysis    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Title Author Date Type Operation

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets

Journal Article

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies

Journal Article

Mechanistic insights into the selective photocatalytic degradation of dyes over TiO/ZSM-11

Journal Article

Recent advances in cycloaddition of CO with epoxides: halogen-free catalysis and mechanistic insights

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Improved film evaporator for mechanistic understanding of microwave-induced separation process

Xin Gao, Dandan Shu, Xingang Li, Hong Li

Journal Article

doping boosted low-temperature NH-SCR activity of FeTiO catalyst: A microstructure analysis and reaction mechanistic

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article